Osteosarcoma of the hard palate in a dog - case report / [Osteossarcoma em palato duro de cão - relato de caso]

The osteosarcoma (OSA) is the most diagnosed primary bone cancer in canine patients. This work reports a case of a canine, six years old, mongrel, female, intact, with an OSA in the hard palate. Physical examination detected a firm mass in the palate. Thoracic radiographs, hematological and biochemical exams, histopathological exams and computed tomography were requested. A chondroblastic OSA was diagnosed and the tumor was characterized by immunohistochemistry. There was never evidence of metastasis in this case. The treatment consisted of the combination of conventional chemotherapy, metronomic chemotherapy, and palliative care, aiming at greater survival and well-being of the patient since surgical excision was not possible due to the location and extension of the tumor. Osteogenic sarcomas of the hard palate are rarely seen and described in the literature. In this article we present a characterization of the osteosarcoma with uncommon localization in the hard palate.(AU)

O osteossarcoma (OSA) é a neoplasia óssea primária mais diagnosticada em pacientes caninos. Este trabalho relata o caso de um canino, com seis anos de idade, sem raça definida, fêmea, não castrado, apresentando OSA em região de palato duro. Ao exame clínico, constatou-se uma massa de consistência firme em região palatina. Além do exame clínico, foram solicitadas radiografias torácicas, exames hematológicos e bioquímicos, exames histopatológicos e tomografia computadorizada. Fora então dado o diagnóstico de OSA condroblástico, e o tumor foi caracterizado pela imuno-histoquímica. Não foram observadas evidências de metástases nesse caso. O tratamento instituído consistiu na combinação de quimioterapia convencional, quimioterapia metronômica e cuidados paliativos, almejando maior sobrevida e bem-estar do paciente, uma vez que a excisão cirúrgica não foi possível devido à localização e à extensão do tumor. Neste artigo, apresentou-se uma caracterização do osteossarcoma com localização incomum no palato duro.(AU)

Non-ulcerated necrotizing sialometaplasia may mimic a salivary gland tumor

Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. The diagnosis becomes a challenge in non-ulcerated NS cases which is essential to rule out the possibility of salivary gland tumors, especially the malignant ones. Here, we presented a case of a 32-year-old male patient with a 1-month complaint of a painful, slightly elevated erythematous area on the hard palate. Incisional biopsy was performed, and NS was diagnosed based on histopathological and immunohistochemical analyses. Clinicians should be aware of and consider NS as a differential diagnosis of minor salivary gland tumors, particularly when it presents as a non-ulcerated clinical aspect.

Developmental association of palatal dimensions and palatal rugae characteristics in Angle´s classes I, II and III of malocclusion / Asociación de desarrollo de las dimensiones palatinas y las características de las rugas palatinas en las clases I, II y III de maloclusión de Angle

During development, bony changes in the palate are reflected in the palatal rugae. Therefore, we hypothesized that the palatal dimensions (PD) influence the shape and number of palatal rugae (PR). The objectives were to record the palatal rugae characteristics (PRC) and palatal dimensions (intercanine distance (ICD), intermolar distance (IMD), palatal height (PH) and palatal area (PA) in Classes I, II and III malocclusion patients and investigate their interrelationship, and statistically examine the possibility of predicting PRC with the PD. Four hundred eighty-one pre-orthodontic study casts of healthy patients with normal palate anatomy were grouped as Classes I, II and III and scanned using 3D cast scanner. The PRC, ICD, IMD, PH, and PA were recorded digitally using 3D enabled software. The data was statistically analyzed. A strong statistically significant difference was observed between PA and number of straight and wavy rugae. ICD and the number of straight rugae were also related. A weak correlation exists between malocclusion classes and PA. The remaining rugae characteristics did not exhibit any relation with palatal dimensions. PA is positively related to the number of straight rugae and negatively related to the number of wavy rugae. Bigger palates have more straight rugae and less number of wavy rugae. A weak correlation between PA and Angle's class I malocclusion exists. We also propose that PA has a developmental association with the number and shape of PR.

Durante el desarrollo, los cambios óseos en el paladar se reflejan en las rugas palatinas. Por lo tanto, planteamos la hipótesis de que las dimensiones palatinas influyen en la forma y el número de las rugas palatinas. Los objetivos fueron registrar las características de las rugas palatinas y las dimensiones palatales (distancia intercanina, distancia intermolar, altura palatina y área palatina) en pacientes con maloclusión de clases I, II y III e investigar su interrelación, y examinar estadísticamente la posibilidad de predecir las características de las rugas palatinas con las dimensiones palatinas. Cuatrocientos ochenta y un estudios pre-ortodónticos de pacientes sanos con anatomía normal del paladar se agruparon como Clases I, II y III y se escanearon con un escáner de emisión 3D. La distancia intercanina, distancia inter molar, altura palatina y área palatina se registraron digitalmente utilizando el software 3D. Los datos se analizaron estadísticamente. Se observó una diferencia estadísticamente significativa entre la altura palatina y el número de rugas rectas y onduladas. Se registró también la distancia intercanina y el número de rugas rectas. Existe una correlación débil entre las clases de maloclusión y la altura palatina. Las características restantes de las rugas palatinas no mostraron ninguna relación con las dimensiones palatinas. El área palatina está relacionada positivamente con el número de rugas rectas y negativamente relacionada con el número de rugas onduladas. Los paladares más grandes tienen más rugas rectas y menor cantidad de rugas onduladas. Existe una correlación débil entre el área palatina y la clase I de maloclusión de Angle. También proponemos que el área palatina tiene una asociación de desarrollo con el número y la forma de rugas palatinas.

Um raro diagnóstico de osteoma periférico em palato duro: relato de caso / A rare diagnosis of peripheral osteoma in the hard palate: case report

Objetivo: relatar uma biópsia excisional de um osteoma periférico no palato duro direito de uma paciente jovem, do sexo feminino e não sindrômica. Relato de caso: paciente do sexo feminino, 32 anos de idade, melanoderma e normossitêmico, buscou atendimento no ambulatório de diagnóstico estomatológico da Faculdade de Odontologia da Universidade Federal de Uberlândia com queixa quanto ao surgimento de lesão na região de palato. Após avaliação clínica e imaginológica, foi decidido realizar biópsia excisional sob anestesia local da lesão. Foram levantadas três hipóteses de diagnóstico: osteoma periférico, exostose ou osteossarcoma. O material coletado foi enviado para análise histopatológica, que confirmou a hipótese de osteoma periférico. Considerações finais: os osteomas periféricos na região de palato duro são raríssimos. Essa lesão geralmente é assintomática ­ exceto quando há impacto traumático durante a mastigação ­, de crescimento lento, podendo se desenvolver em osso cortical ou medular. O tratamento de escolha é a remoção cirúrgica e o índice de recorrência é raro. O caso enfatiza a condição rara, pois foram encontrados apenas seis casos semelhantes relacionados na literatura. (AU)

Objective: To report an excisional biopsy of a peripheral osteoma in the right hard palate in a non-syndromic young female patient. Case Report: A 32-year-old female patient, black, and normosystemic sought assistance in the stomatological diagnosis outpatient clinic of the School of Dentistry of the Federal University of Uberlândia, Brazil, complaining about the appearance of a lesion in the palate region. After clinical and imaging assessment, it was decided to perform an excisional biopsy under local anesthesia of the lesion. Three diagnostic hypotheses were raised - peripheral osteoma, exostosis, or osteosarcoma. The material collected was sent for histopathological analysis, which confirmed the hypothesis of peripheral osteoma. Final considerations: Peripheral osteomas in the hard palate region are very rare. This lesion is usually asymptomatic, except when there is a slow-growing chewing impact during mastication, which may develop in cortical or spinal bone. Surgical removal is the treatment of choice and the rate of recurrence is rare. The case emphasizes the rare condition, considering only six similar cases were found in the literature. (AU)

Oral focal mucinosis of the hard palate and gingiva

Oral focal mucinosis (OFM) is an uncommon, asymptomatic, submucosal, slow-growing nodule representing a counterpart of the cutaneous focal mucinosis (CFM). OFM has a female predilection with the highest prevalence in the fifth decade of life. About 68% of OFMs occur in the gingiva and 14% in the palate. We present the case of a 41-year-old woman presenting a progressively growing mass on the palate, since the last 8 months. The diagnostic workup led to the diagnosis of an unusual OFM with the clinical presentation involving the gingiva and hard palate. This case report discusses the clinical and histopathological differential diagnosis.

Estomatitis Urémica como Complicación Oral de Insuficiencia Renal Crónica: Reporte de Caso y Revisión de la Literatura / Uremic Stomatitis as an Oral Complication of Chronic Renal Failure: Case Report and Literature Review

RESUMEN: La Estomatitis Urémica es una lesión oral poco frecuente que se presenta generalmente en pacientes con insuficiencia renal crónica avanzada o no tratada. A continuación, se reporta un caso clínico de un paciente masculino de 22 años de edad que acude a un servicio de urgencia con la presencia de placas blanquecinas indoloras en piso de boca, cara interna de mejilla, y lengua. Las probables causas, presentaciones clínicas, y manejo odontológico son discutidos.

ABSTRACT: Uremic stomatitis is a rare oral lesion that usually occurs in patients with advanced or untreated chronic renal failure. Here we report a case of a 22-year-old male patient who comes to an emergency department with the presence of painless whitish plaques on the floor of the mouth, internal cheek face, and tongue. Probable causes, clinical presentations, and dental management are discussed.

Tratamiento de fistula palatina anterior mediante colgajo de lengua / Treatment of anterior palatal fistula through tongue flap

La fístula palatina anterior es la comunicación anormal entre la cavidad oral y la nariz que se presenta después del cierre quirúrgico de la fisura palatina, ésta ocurre con más frecuencia en defectos de paladar duro. El colgajo de lengua está indicado para la reconstrucción de grandes fístulas palatinas y con excesivas cicatrices palatinas luego de varios procedimientos insatisfactorios. El colgajo ofrece varias ventajas ya que presenta abundante tejido, excelente irrigación y es de fácil rotación. El resultado fue satisfactorio.

The anterior palatal fistula is the abnormal communication between the oral cavity and nose that occurs after surgical closure of cleft palate, this occurs more frequently in hard palate defects. Tongue flap is indicated for the reconstruction of large fistulas and excessive palatal scars after several unsatisfactory procedures. The flap offers several advantages since it presents abundant tissue, excellent irrigation and easy rotation. The result was satisfactory.

Palatal Pleomorphic Adenoma in a Pediatric Patient: Case Report / Adenoma Pleomorfo Palatino en un Paciente Pediátrico: Reporte de Caso

Pleomorphic adenoma is the most common benign neoplasm of salivary glands. Their common location is in parotid gland, however, a lower percentage of these tumors might occur in minor glands. The epidemiology of this tumor shows that adults are the most affected, with rare occurrence in children or adolescents. We present the case report of pleomorphic adenoma located on the palate of a 10 year old. Excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed ductal structures surrounded by plasmacytoid mioepithelial cells within a myxoid stroma, the final diagnosis corresponded to Pleomorphic Adenoma. Early detection and excision of this lesion in children are important to minimize potential recurrences or malignant transformation.

El adenoma pleomorfo es la neoplasia benigna más común de las glándulas salivales. Su localización común está en glándula parótida, sin embargo, un bajo porcentaje de estos tumores puede ocurrir en glándulas menores. La epidemiología de este tumor muestra que los adultos son los más afectados, con rara ocurrencia en niños o adolescentes. Presentamos el caso de un adenoma pleomorfo localizado en el paladar de un niño de 10 años. La biopsia excisional de la lesión seguida de examen histopatológico de la muestra de biopsia reveló estructuras ductales rodeadas por células mioepiteliales plasmocitóides dentro de un estroma mixoide, siendo el diagnóstico final adenoma pleomorfo. La detección temprana y la excisión de esta lesión en los niños es importante para minimizar las recidivas potenciales o la transformación maligna.

Pleomorphic Adenoma of Hard Palate: A Case Report and Review of Literature.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma has unusual histopathologic features. It is the most common benign tumor affecting both major and minor salivary glands. Parotid salivary gland is affected mostly in the major group, and palate is the most common site affected in minor salivary glands. The upper lip is the second most common site followed by buccal mucosa. Less than 3% of the salivary gland tumors account for head and neck tumors. In few cases, benign pleomorphic adenoma may turn malignant also. In this case report, a female patient aged 32 years who reported with a complaint of painless swelling in the palate is presented.

Pleomorphic adenoma of the palate: two cases report and literature review / Adenoma pleomorfo palatino: reporte de 2 casos y revisión de la literatura

Pleomorphic adenoma (PA) is the most common neoplasm encountered in major and minor salivary glands. Intraorally, it is most frequently developed in the palatal glands. Histologically, it is characterized by a diverse architecture comprised of epithelial stromal elements mixed with mucoid, myxoid, or chondroid fibrohyaline. A PA does not generally present gender bias and can occur at any age with the same clinical behavior. It is usually a round, slow-growing, painless tumor, which is firm upon palpation. We reported two cases of adult patients who were treated using transoral resection at San Juan de Dios Hospital in La Serena.

El Adenoma Pleomorfo es la neoplasia más común de las glándulas salivales mayores y menores. Intraoralmente las glándulas del paladar son las más afectadas. Histológicamente se caracteriza por una arquitectura variada que comprende elementos epiteliales mezclados con estroma mucoide, mixoide, fibrohialino o condroide, Los AP no suelen presentar predisposición por sexos, pudiendo aparecer a cualquier edad, con el mismo comportamiento clínico. Se presentan habitualmente como una tumoración redondeada de crecimiento lento, indolora y firme a la palpación. Presentamos dos casos de pacientes adultos, quienes fueron tratados mediante resección transoral en el hospital de la Serena.

Expressão imuno-histoquímica de proteínas relacionadas com a absorção óssea em carcinoma epidermoide de palato duro e língua / Immunohistochemical expression of proteins related to bone resorption in squamous cell carcinoma of the hard palate and tongue

O carcinoma epidermóide oral (CEO) apresenta uma tendência marcante de invadir o osso quando localizado em palato duro e rebordo. O mecanismo preciso desta invasão permanece incompletamente descrito, apesar de sugerirem na literatura que a destruição óssea, invasão e metástase seja mediada por osteoclastos e não diretamente por células do carcinoma. As moléculas RANK/RANKL /OPG são fundamentais na oesteoclastogênese, assim como a IL-6 que regula suas expressões. O objetivo desta pesquisa foi avaliar a expressão imuno-histoquímica de fatores de reabsorção óssea (RANKL e OPG) e da citocina (IL-6) no carcinoma epidermóide de palato duro (com invasão óssea) e língua (sem invasão óssea), correlacionandoas com os parâmetros clinicopatológicos e prognósticos. A amostra foi constituída por 30 carcinomas epidermóides com invasão óssea (localizados no palato) e 31 sem invasão óssea (localizados na língua). Foram avaliados a intensidade e a média das células tumorais, estromais e inflamatórias imunomarcadas para os anticorpos anti-RANKL, anti-OPG e anti-IL-6, no front de invasão e no centro tumoral. O escore (s) da imunorreatividade das células foi estabelecido através da multiplicação do percentual de células positivas (P) pelo valor da intensidade da marcação (I) (S = P x I), em cinco campos (400×). A análise da expressão da proteína RANKL foi significativamente mais expressa (p=0,002) nas células inflamatórias, com tendência há uma maior expressão nas células dos carcinomas epidermóides do palato duro. Entre os parâmetros clinicopatológicos foi observado associação do RANKL com o pior prognóstico, com significância estatística apenas para o estágio avançado do tumor (p= 0,033). A OPG demonstrou fraca expressão tanto nos casos de língua (0,77 ±1,85) quanto de palato duro (1,32 ± 2,48), com ausência de significância estatística (p>0,05). Em relação aos parâmetros clinicopatológicos a OPG apresentou tendência de associação com o pior prognóstico, com associação estatística significante para o óbito (p=0,048) e invasão perivascular (p=0,047). A IL-6 foi significantemente mais expressa (p<0,001) em células tumorais e inflamatórias nos carcinomas epidermóides de palato duro. E dentre os parâmetros clinicopatológicos, a IL-6 apresentou tendência de associação com o bom prognóstico, com diferença estatística para a ausência de metástase e as células tumorais (p = 0,020), estromais (p = 0,027) e inflamatórias (p = 0,017). Com base nos resultados pode-se concluir que a IL-6 pode ser utilizada como um marcador do carcinoma epidermóide oral com invasão óssea, e que a relação RANKL/OPG está alterada no carcinoma epidermóide oral. (AU)

Oral squamous cell carcinoma (CEO ) has a marked tendency to invade the bone when located in the palate and lip . The precise mechanism of this invasion is still not completely described , although the literature suggests that the bone destruction ABSTRAT , invasion and metastasis is mediated by osteoclasts and not directly by carcinoma cells . The molecules RANK / RANKL / OPG are fundamental in oesteoclastogênese, and IL-6 that regulates its expression. The objective of this research was to evaluate the immunohistochemical expression of factors of bone resorption ( RANKL and OPG ) and cytokine ( IL - 6 ) in squamous cell carcinoma of the hard palate (with bone invasion ) and tongue (without bone invasion ) , correlating with the clinicopathological parameters and prognosis. The sample consisted of 30 squamous cell carcinoma with bone invasion (located on the palate) and 31 without bone invasion (located on the tongue). Were evaluated and the average intensity of the tumor cells , stromal and inflammatory immunostained for anti-RANKL antibodies , anti- OPG and anti -IL- 6 at the invasive front and center of the tumor. The score (s) of the immunoreactivity of cells was established by multiplying the percentage of positive cells (P) for marking intensity value (I) (S = P x I) in five fields (× 400). The analysis of the expression of RANKL protein was expressed significantly higher (p = 0.002) in inflammatory cells, there is a trend to higher expression in squamous cell carcinomas of the hard palate. Among the clinicopathologic parameters was observed association of RANKL with the worst prognosis, with statistical significance only for the advanced stage of the tumor (p = 0.033). The OPG showed weak expression both in cases of tongue (0.77 ± 1.85) and hard palate (1.32 ± 2.48), with no statistical significance (p > .05). In relation to clinicopathological parameters OPG tended association with worse prognosis, with a statistically significant association for death (p = 0.048) and perivascular invasion (p = 0.047). IL- 6 was expressed significantly more (p < 0.001) in tumor and inflammatory cells in squamous cell carcinoma of the hard palate. In addition, among the clinicopathologic parameters, IL- 6 showed a tendency of association with good prognosis, with a statistical difference for the absence of metastasis and tumor cells (p = 0.020), stromal (p = 0.027) and inflammatory (p = 0.017). Based on the results it can be concluded that IL -6 may be used as a marker of oral squamous cell carcinoma with bone invasion, and the ratio RANKL / OPG is changed in oral squamous cell carcinoma. (AU)

Exposición espontánea de un torus palatino de la línea media / Spontaneous exposition of a midline palatal torus

Introducción. El torus , o rodete, palatino es una alteración ósea benigna que puede generar molestias en la fonación y en la deglución. Cuando su crecimiento o exposición persistente producen síntomas molestos, debe ser resecado quirúrgicamente. Presentación del caso. Se trata de una paciente de 82 años de edad, que consultó por una lesión ulcerativa de un año de evolución, que producía dolor, halitosis y molestia a la deglución. En el examen físico de la cavidad oral, se observó una prominencia de consistencia dura en la línea media, con perforación y ulceración de la mucosa palatina en su porción lateral posterior izquierda. Se consideraron los diagnósticos de torus palatino, osteoma, granuloma piógeno y neoplasia de tejidos blandos. Se decidió resecarla quirúrgicamente y hacer el estudio histopatológico. La evolución clínica fue satisfactoria, con resolución completa un mes después de la cirugía. En el estudio de histopatología se observó hiperostosis ósea con inflamación crónica de los tejidos blandos e hiperplasia simple de la mucosa, que corresponden a un torus palatino. Discusión. Se reporta un inusual caso de exposición espontánea de un torus palatino que ocupaba casi toda la bóveda palatina, se describe su resección quirúrgica y se informan los hallazgos de histopatología. En la revisión bibliográfica realizada, no se encontró un reporte previo de exposición espontánea de torus palatino.

Introduction: Palatal torus, or torus palatinus, is a benign bone alteration that may cause some discomfort during phonation or swallowing. When its growth or persistent exposition produces unpleasant symptoms, it must be surgically removed. Case presentation: We treated an 82-year-old female patient who consulted for a painful ulcerous lesion she had had for a year and which produced halitosis and discomfort when swallowing. During the oral cavity physical exam we observed a hard protuberance on the midline. It showed a perforation and ulceration of the lateral posterior palatal mucosa on the left side. We considered the following diagnosis: palatal torus, osteoma, pyogenic granuloma, or a soft-tissue neoplasia. We decided to surgically remove it and to perform a histopathological examination. Clinical evolution was satisfactory with complete resolution one month after surgery. The histopathological examination showed hyperostosis along with chronic inflammation of the soft tissues and a simple hyperplasia of the mucosa, which in turn indicated a palatal torus. Discussion: We report an unusual case of spontaneous exposition of a palatal torus which took up almost all of the hard palate area. Its resection is described and we inform the histopathological findings. In the literature review, we did not find a previous report of a spontaneous exposition of a palatal torus.

Incisive papilla as a bio-metric guide in the arrangement of teeth

When natural teeth are lost it becomes difficult to arrange the teeth in their original position in the complete dentures. A variety of guides has been suggested for arranging teeth and are called the Bio-Metric guides. Incisive Papilla is a commonly used and a reliable landmark in the arrangement of anterior teeth. Different values are reported for the distance between it the anterior teeth. The points of measurement, its methods and accuracy would help to decide on the right value to be used

Dimensões do palato duro de respiradores nasais e orais por diferentes etiologias / Hard palate dimensions in nasal and mouth breathers from different etiologies

OBJETIVO: Comparar as dimensões do palato duro de crianças respiradoras nasais, respiradoras orais por etiologia obstrutiva e respiradoras orais por etiologia viciosa. MÉTODOS: A amostra foi composta por 76 crianças, 37 meninos e 39 meninas, com média de idade de 9,32±1,16 anos, distribuídas conforme diagnóstico do modo respiratório e etiologia da respiração oral. Foram obtidos modelos em gesso do arco dental maxilar para a realização de medidas do palato duro com paquímetro digital. Foram obtidas as medidas transversais, verticais e do comprimento anteroposterior do palato duro. A comparação das medidas do palato duro entre os grupos foi realizada por meio de testes estatísticos. RESULTADOS: Na comparação das dimensões do palato duro entre os grupos de respiradores nasais e respiradores orais, verificou-se diferença na distância e profundidade ao nível dos segundos pré-molares e na distância entre os primeiros molares. Também foi verificada diferença entre os grupos de respiradores orais por etiologia obstrutiva e por etiologia viciosa na profundidade do palato duro ao nível dos caninos. CONCLUSÃO: Respiradores orais apresentam palato duro mais estreito ao nível dos segundos pré-molares e primeiros molares, e mais profundo ao nível dos segundos pré-molares quando comparados aos respiradores nasais. Evidencia-se também que os respiradores orais por etiologia viciosa apresentam maior profundidade do palato duro ao nível dos caninos quando comparados aos respiradores orais por etiologia obstrutiva.

PURPOSE: To compare the hard palate dimensions of nasal-breathing children, mouth breathers from obstructive etiology, and habitual mouth breathers. METHODS: The sample comprised 76 children, 37 boys and 39 girls, with mean age of 9.32±1.16 years, distributed according to the diagnosis of breathing mode and to the etiology of mouth breathing. Plaster cast models of the subjects' superior dental arch were obtained in order to measure the hard palate with a digital caliper. Measurements of transverse, vertical and anteroposterior palatal length were taken. The hard palate measures were compared among the groups through statistical analysis. RESULTS: The comparison of hard palate dimensions observed in nasal and mouth breathers showed differences regarding the distance and depth of second premolars, and the distance of first molars. Differences were also found between the groups of mouth breathers regarding the hard palate depth at the level of canines. CONCLUSION: Mouth breathers showed narrower hard palate at the level of second premolars and first molars, and deeper palate in the level of second premolars, when compared to nasal breathers. It is evidenced that habitual mouth breathers presented deeper hard palate at the level of canines, when compared to mouth breathers from obstructive etiology.

Darier disease with oral and esophageal involvement: A case report.

A 58-year-old man presented with itchy papular eruptions all over the body since 15 years. Intraoral examination revealed raised papular lesions on the labial mucosa, hard palate, and tongue. The histopathology of the oral and skin lesions was confirmative of Darier disease (DD). This patient also showed esophageal involvement, which was confirmed histopathologically. Such a presentation of DD, with oral and esophageal involvement, is rare.

Maffucci’s Syndrome: report of a case with oral manifestation / Síndrome de Maffucci: relato de caso com manifestação oral

Introduction: Maffucci’s Syndrome is a rare nonhereditary mesodermal dysplasia consisting of multiple haemangioma of the soft tissue and enchondromas, mostly affecting phalanges and long bones. The syndrome can also be associated with a variety of other benign and malignant tumors. Case report: Here we report a case of Maffucci’s Syndrome and haemangioma of lip and palate which is rare in this syndrome. This case report describes an 18 year old boy with multiple nodular soft tissue swellings involving the anterior hard palate and lower labial mucosa and bony abnormalities (enchondromas) involving the lower limb.

Introdução: A Síndrome de Maffucci é uma displasia mesodermal não hereditária rara. Consiste de múltiploshemangiomas de tecido mole e encondromas, a maioria afetando as falanges e os ossos longos. A síndromepode também estar associada a uma variedade de tumores benignos e malignos. Relato de caso: O presente trabalho apresenta um caso de Síndrome de Maffucci e hemangioma de lábio e palato, o que é raro nessa síndrome, descrevendo o caso de um garoto de 18 anos de idade com inchaços nodulares múltiplos de tecido mole envolvendo o palato duro anterior e a mucosa labial inferior, além de anomalias ósseas (encondromas)acometendo um membro inferior.

Carcinoma espinocelular de paladar: presentación de un caso / Spinocellular carcinoma of palate: a case presentation

El cáncer en Cuba es la segunda causa de muerte para todos los grupos de edades y el carcinoma espinocelular de la cavidad bucal ocupa el sexto lugar en frecuencia, con mayor incidencia a partir de la quinta década de la vida y raramente en pacientes jóvenes. Se presenta el caso de un hombre blanco de 25 años, con antecedente de retardo mental ligero, que acude a consulta de Cirugía Máxilo Facial por presentar aumento de volumen en región posterosuperior de paladar. Se realizan exámenes complementarios y biopsia. El Departamento de Anatomía Patológica informa diagnóstico de carcinoma espinocelular.

Cancer is the second case of death in Cuba for all ages group and spinocellular carcinoma of oral cavity occupies the sixth place, the highest incidence was from the fifth decade of life and rarely in young patients. A case of a 25 years old white man is presented, with mild mental retardation antecedents, he arrives to maxillofacial surgery for presenting volume increase in posterosuperior region of palate. Complementary exams and biopsy are carried out. The Pathological Anatomy Department informs spinocellular carcinoma diagnosis.

Effect of carbonated drink on excisional palatal wound healing: A study on Wistar rats.

Background: Millions of people worldwide consume carbonated drinks every day. The effects of these drinks on hard tissues in the mouth have been proved beyond doubt. Only a little has been done so far to assess the effects of carbonated drinks on oral soft tissues. This study was an attempt to assess the effect of carbonated drinks on oral wound healing. Materials and Methods: Twenty female Wistar rats were considered for the study. A circular wound was created on the palate and the animals were divided into two groups (experimental and control group). The experimental group animals were fed with a commercially available carbonated drink instead of water, and two animals from each group were euthanized at 3, 7, 14 and 21 days. Wound site was assessed morphometrically and histologically. Results: There was a marked difference in the healing pattern between the experimental group and control group animals. Control group animals showed a normal healing pattern with formation of a fibrous connective tissue at the end of 21 days. In the experimental group, healing was delayed and disrupted. The wound site showed a definite palatal perforation in experimental group animals after 14 days, but osteoclasts were not noticed in the histological sections. Conclusion: Consumption of carbonated drinks can disrupt oral wound healing. Results suggest that the bone changes seen in experimental group samples are not mediated by osteoclasts, and acidity of the carbonated drinks could be one of the reasons for these changes.

Surgical management of nasopalatine duct cyst: case report / Tratamento cirúrgico do cisto nasopalatino: relato de caso

OBJECTIVE: To present a case and discuss the clinicopathological characteristics of nasopalatine duct cyst and discuss the etiology, diagnosis, treatment and prognosis, with a review of the literature. DISCUSSION: Nasopalatine duct cyst occurs in approximately 1% of the population. Presentation may be asymptomatic or include swelling, pain, and drainage from the hard palate. Surgical treatment was carried out under local anesthesia and comprised the dissection and removal of the cyst adopting a usually palatine approach.

OBJETIVO: Apresentar um caso e discutir as características clínico-patológicas do cisto de ducto nasopalatino, discutinfo a etiologia, diagnóstico, tratamento e prognóstico, revisando a literatura. DISCUSSÃO: Os cistos naso-palatinos ocorrem em aproximadamente 1% da população. A apresentação pode ser assintomática ou incluir edema, dor e drenagem purulenta do palato duro. O tratamento cirúrgico foi sob anestesia local e constituiu de dissecção e remoção do cisto, via acesso palatino.

Schwannoma de paladar duro: reporte de un caso y revisión bibliográfica / Schwannoma of the hard palate: report of a case and review of the literature

Los neurilemomas o shwannomas son tumores neurogénicos benignos con origen en la vaina neural. Aproximadamente un 25 a 45 por cinto ocurren en cabeza y cuello y sóloun 1 por ciento tiene origen intraoral, siendo frecuentes en la superficie dorsal de la lengua y en menor grado en paladar, piso de boca, encías, labios y mandíbulas. Suele presentarse entre la tercera y cuarta década de vida, con igual frecuencia entre hombres y mujeres. Es un tumor claramente circunscripto, de tamaño pequeño, de crecimiento lento y gradual. El examen microscópico es necesario para el diagnóstico. El tratamiento de elección es la eliminación quirúrgica completa y después de ésta es rara su recurrencia. Se presenta un caso de schwannoma de rara localización, además de abordar las posibilidades diagnósticas y de tratamiento.